Cytoreductive Surgery With Intraperitoneal Chemotherapy to Treat Pseudomyxoma Peritonei at Nonspecialized Hospitals

Surg Today. 2011 Sep;41(9):1219-23. doi: 10.1007/s00595-010-4495-6. Epub 2011 Aug 26.

Abstract

Purpose: It has been reported that complete cytoreduction using peritonectomy combined with intraperitoneal chemotherapy improves the prognosis of patients with pseudomyxoma peritonei (PMP); however, this treatment strategy remains controversial, especially at nonspecialized institutes, because of its high morbidity rate.

Methods: We reviewed the clinical records of 15 consecutive patients with PMP, treated in nonspecialized hospitals and observed by one of us between 1999 and 2010. Cytoreductive surgery was done using peritonectomy procedures with intraperitoneal chemotherapy and was performed with curative intent, |in accordance with Sugarbaker.

Results: All patients had mucinous tumors disseminated in the peritoneal cavity. Complete cytoreduction was achieved in 12 patients. Morbidity was 40% (6/15) and mortality was 0% (0/15). After a median follow-up period of 43 months, the 12 patients who underwent complete cytoreduction were disease-free with good quality of life, and 1 of the 3 patients who underwent incomplete cytoreduction was alive with disease.

Conclusions: These findings suggest that peritonectomy with intraperitoneal chemotherapy for PMP can provide prognostic benefit, even at nonspecialized hospitals. Considering the treatment risk, it should ideally be performed at a referral center, or at least by an experienced surgeon.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cisplatin / administration & dosage*
  • Combined Modality Therapy
  • Cryosurgery*
  • Female
  • Hospitals
  • Humans
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Peritoneal Neoplasms / drug therapy
  • Peritoneal Neoplasms / mortality
  • Peritoneal Neoplasms / surgery*
  • Postoperative Complications / epidemiology
  • Pseudomyxoma Peritonei / drug therapy
  • Pseudomyxoma Peritonei / mortality
  • Pseudomyxoma Peritonei / surgery*
  • Retrospective Studies
  • Survival Analysis
  • Survival Rate
  • Treatment Outcome

Substances

  • Mitomycin
  • Cisplatin