Preliminary report on the expression of leptin and leptin receptor (ObR) in normal, hyperplastic and neoplastic canine mammary tissues

Res Vet Sci. 2012 Aug;93(1):343-9. doi: 10.1016/j.rvsc.2011.07.020. Epub 2011 Aug 27.

Abstract

Leptin and its receptor (ObR) expression were investigated by immunohistochemistry in normal, hyperplastic and neoplastic canine mammary tissues and related to clinical-pathological features. Leptin expression was detected in healthy mammary tissues, adenosis and in benign mammary tumours and was lower in ductal hyperplasias and malignant tumours. A high percentage of ObR-positive cells were present in adenosis, benign tumours and in complex carcinomas, while ObR expression was lower in healthy mammary tissues, in ductal hyperplasias and in a large part of invasive mammary carcinomas. Our data demonstrated that cancer cells expressed at low level leptin and ObR in canine mammary tumours with a more aggressive behaviour, as well as in lymph node metastases. Consequently, leptin and ObR expressions in this species resulted to be not associated with a reduced overall survival.

MeSH terms

  • Animals
  • Dog Diseases / metabolism*
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Hyperplasia / metabolism
  • Hyperplasia / veterinary
  • Leptin / analysis
  • Leptin / biosynthesis*
  • Mammary Glands, Animal / chemistry
  • Mammary Glands, Animal / metabolism*
  • Mammary Glands, Animal / pathology
  • Mammary Neoplasms, Animal / chemistry
  • Mammary Neoplasms, Animal / metabolism*
  • Mammary Neoplasms, Animal / pathology
  • Receptors, Leptin / analysis
  • Receptors, Leptin / biosynthesis*

Substances

  • Leptin
  • Receptors, Leptin