Analysis of prognostic factors in disseminated prostatic cancer. An update. Dutch Southeastern Urological Cooperative Group

Cancer. 1990 Jun 15;65(12):2758-61. doi: 10.1002/1097-0142(19900615)65:12<2758::aid-cncr2820651225>3.0.co;2-6.

Abstract

A statistical analysis of prognostic factors in 175 patients with hormonally treated disseminated prostatic cancer was done. The prognostic significance of performance status (PS), hemoglobin (Hb), alkaline phosphatase (Alk P), and testosterone was assessed with a univariate analysis. The authors did not find significant prognostic value in age, tumor size or grade, prostatic acid phosphatase, and prostate-specific antigen in these patients. In a multivariate logistic model (Cox regression), PS, Hb, and Alk P were found useful for dividing patients into prognostic groups. The prognosis for high-risk patients on standard hormonal treatment was very poor. The authors concluded that research on prognostic factors is useful and permits a division of patients into risk groups that makes choice of treatment more accurate. The use of new treatment combinations as a start treatment is appropriate for high-risk patients with disseminated prostatic cancer.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Phosphatase / analysis
  • Aged
  • Aged, 80 and over
  • Alkaline Phosphatase / analysis
  • Androgen Antagonists / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Follow-Up Studies
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Humans
  • Imidazoles / therapeutic use
  • Imidazolidines*
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Prognosis
  • Prostate / enzymology
  • Prostatic Neoplasms / analysis
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / enzymology
  • Prostatic Neoplasms / surgery
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Testosterone / analysis

Substances

  • Androgen Antagonists
  • Antineoplastic Agents
  • Imidazoles
  • Imidazolidines
  • Gonadotropin-Releasing Hormone
  • Testosterone
  • nilutamide
  • Alkaline Phosphatase
  • Acid Phosphatase