The Rotterdam Study: 2012 objectives and design update

Eur J Epidemiol. 2011 Aug;26(8):657-86. doi: 10.1007/s10654-011-9610-5. Epub 2011 Aug 30.


The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over a 1,000 research articles and reports (see ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chronic Disease / epidemiology*
  • Cohort Studies
  • Epidemiologic Research Design*
  • Female
  • Humans
  • Incidence
  • Life Expectancy / trends*
  • Male
  • Middle Aged
  • Netherlands
  • Population Dynamics*
  • Risk Assessment