Animal tumor models for PET in drug development

Ann Nucl Med. 2011 Dec;25(10):717-31. doi: 10.1007/s12149-011-0531-x. Epub 2011 Aug 31.

Abstract

Positron emission tomography (PET) is being increasingly applied to animal tumor models due to the need for proof-of-concept testing and preclinical efficacy studies of anticancer agents. Regardless of the nature of an experiment, investigators should carefully select a suitable animal tumor model as part of the experimental design. This review introduces sources of information and the guiding principles regarding applicability of various animal tumor models for PET in anticancer agent development especially for small animals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Disease Models, Animal*
  • Drug Discovery / methods*
  • Endocrine System / drug effects
  • Endocrine System / metabolism
  • Humans
  • Neoplasms / diagnostic imaging*
  • Neoplasms / drug therapy*
  • Positron-Emission Tomography / methods*
  • Radioactive Tracers

Substances

  • Radioactive Tracers