Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

J Neural Transm (Vienna). 2012 Mar;119(3):313-8. doi: 10.1007/s00702-011-0709-3. Epub 2011 Aug 31.


Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Cognition / physiology*
  • Female
  • Genotype
  • Humans
  • Intelligence / genetics*
  • Intelligence Tests
  • Male
  • Memory / physiology
  • Middle Aged
  • Neuropsychological Tests
  • Polymorphism, Single Nucleotide
  • Receptors, Interleukin-6 / genetics*


  • Receptors, Interleukin-6
  • interleukin-6 receptor alpha