Diverse Metabolic Profiles of a Streptomyces Strain Isolated From a Hyper-Arid Environment

J Nat Prod. 2011 Sep 23;74(9):1965-71. doi: 10.1021/np200470u. Epub 2011 Aug 31.

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Cinnamates / chemistry
  • Cinnamates / isolation & purification
  • Escherichia coli / drug effects
  • Hygromycin B / analogs & derivatives
  • Hygromycin B / chemistry
  • Hygromycin B / isolation & purification
  • Listeria monocytogenes / drug effects
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology
  • Metabolome
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Staphylococcus aureus / drug effects
  • Streptomyces* / chemistry
  • Streptomyces* / genetics
  • Streptomyces* / metabolism
  • Vibrio / drug effects

Substances

  • Anti-Bacterial Agents
  • Cinnamates
  • Macrolides
  • chaxalactin A
  • chaxalactin B
  • chaxalactin C
  • Hygromycin B
  • hygromycin A