A double-blind, randomized study comparing pure chromated glycerin with chromated glycerin with 1% lidocaine and epinephrine for sclerotherapy of telangiectasias and reticular veins

Dermatol Surg. 2011 Nov;37(11):1590-4. doi: 10.1111/j.1524-4725.2011.02130.x. Epub 2011 Aug 24.


Background: Chromated glycerin (CG) is an effective, although painful, sclerosing agent for telangiectasias and reticular leg veins treatment.

Objective: To determine pain level and relative efficacy of pure or one-third lidocaine-epinephrine 1% mixed chromated glycerin in a prospective randomized double-blind trial.

Method: Patients presenting with telangiectasias and reticular leg veins on the lateral aspect of the thigh (C(1A) or (S) E(P) A(S) P(N1) ) were randomized to receive pure CG or CG mixed with one-third lidocaine-epinephrine 1% (CGX) treatment. Lower limb photographs were taken before and after treatment and analyzed by blinded expert reviewers for efficacy assessment (visual vein disappearance). Patients' pain and satisfaction were assessed using visual analogue scales.

Results: Data from 102 of 110 randomized patients could be evaluated. Patient pain scores were significantly higher when pure CG was used than with CGX (p<.001). Patient satisfaction with treatment outcome was similar in the two groups. Objective visual assessment of vessel disappearance revealed no significant difference between the two agents (p=.07).

Conclusion: Addition of lidocaine-epinephrine 1% to CG, in a ratio of one-third, significantly reduces sclerotherapy pain without affecting efficacy when treating telangiectasias and reticular leg veins.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anesthetics, Local / administration & dosage*
  • Double-Blind Method
  • Epinephrine / administration & dosage*
  • Female
  • Glycerol / administration & dosage*
  • Humans
  • Leg / blood supply
  • Lidocaine / administration & dosage*
  • Middle Aged
  • Pain Measurement
  • Prospective Studies
  • Sclerosing Solutions / administration & dosage*
  • Sclerotherapy*
  • Skin / blood supply
  • Stockings, Compression
  • Telangiectasis / therapy*
  • Varicose Veins / therapy
  • Vasoconstrictor Agents / administration & dosage*
  • Veins / pathology


  • Anesthetics, Local
  • Sclerosing Solutions
  • Vasoconstrictor Agents
  • Lidocaine
  • Glycerol
  • Epinephrine