Ginsenoside Re: pharmacological effects on cardiovascular system

Cardiovasc Ther. 2012 Aug;30(4):e183-8. doi: 10.1111/j.1755-5922.2011.00271.x. Epub 2011 Apr 1.

Abstract

Ginsenosides are the bioactive constituents of ginseng, a key herb in traditional Chinese medicine. As a single component of ginseng, ginsenoside Re (G-Re) belongs to the panaxatriol group. Many reports demonstrated that G-Re possesses the multifaceted beneficial pharmacological effects on cardiovascular system. G-Re has negative effect on cardiac contractility and autorhythmicity. It causes alternations in cardiac electrophysiological properties, which may account for its antiarrhythmic effect. In addition, G-Re also exerts antiischemic effect and induces angiogenic regeneration. In this review, we first outline the chemistry and the pharmacological effects of G-Re on the cardiovascular system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Action Potentials
  • Angiogenesis Inducing Agents / pharmacology
  • Animals
  • Anti-Arrhythmia Agents / pharmacology
  • Cardiotonic Agents / pharmacology
  • Cardiovascular Agents / chemistry
  • Cardiovascular Agents / pharmacology*
  • Cardiovascular System / drug effects*
  • Cardiovascular System / physiopathology
  • Dose-Response Relationship, Drug
  • Ginsenosides / chemistry
  • Ginsenosides / pharmacology*
  • Heart Conduction System / drug effects
  • Heart Conduction System / physiopathology
  • Heart Rate / drug effects
  • Humans
  • Myocardial Contraction / drug effects
  • Neovascularization, Physiologic / drug effects

Substances

  • Angiogenesis Inducing Agents
  • Anti-Arrhythmia Agents
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Ginsenosides
  • ginsenoside Re