Fertility concerns for the aging male

Urology. 2011 Sep;78(3):496-9. doi: 10.1016/j.urology.2011.06.010.


Because of many societal factors, the number of men over the age of 35 desiring to conceive children has increased over the past 40 years. The purpose of this review is to identify the mechanisms of aging on male fertility, to evaluate the genetic risk for the offspring, and to provide counseling for the older male. Most evidence suggests trends that increased paternal age has negative effects on fertility and some genetic risk for offspring, but the age at which the risk develops and the magnitude of risk are poorly defined.

Publication types

  • Review

MeSH terms

  • Adult
  • Aging / physiology*
  • Animals
  • Chromosome Disorders / etiology
  • Fertility / physiology*
  • Humans
  • Infertility, Male / physiopathology
  • Infertility, Male / therapy
  • Male
  • Middle Aged
  • Paternal Age*
  • RNA-Induced Silencing Complex
  • Semen Analysis
  • Sperm Motility


  • RNA-Induced Silencing Complex