Comment
doi: 10.1016/j.cell.2011.08.018.
When T cells run out of breath: the HIF-1α story
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- PMID: 21884928
- DOI: 10.1016/j.cell.2011.08.018
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Comment
When T cells run out of breath: the HIF-1α story
Cell.
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Abstract
In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.Cell. 2011 Sep 2;146(5):772-84. doi: 10.1016/j.cell.2011.07.033. Epub 2011 Aug 25. Cell. 2011. PMID: 21871655 Free PMC article.
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