HDAC3 at the fulcrum of an epithelial-mesenchymal balance

Sendurai A Mani; Michelle Craig Barton

doi:10.1016/j.molcel.2011.08.012

HDAC3 at the fulcrum of an epithelial-mesenchymal balance

Mol Cell. 2011 Sep 2;43(5):697-8. doi: 10.1016/j.molcel.2011.08.012.

Authors

Sendurai A Mani¹, Michelle Craig Barton

Affiliation

¹ Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. smani@mdanderson.org

Abstract

In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.

Publication types

Comment

Grants and funding

R01 DK078024/DK/NIDDK NIH HHS/United States