Converting human skin cells to neurons: a new tool to study and treat brain disorders?

Cell Stem Cell. 2011 Sep 2;9(3):179-81. doi: 10.1016/j.stem.2011.08.004.

Abstract

Recent publications in Cell Stem Cell (Son et al., 2011; Ambasudhan et al., 2011), PNAS (Pfisterer et al., 2011), and Nature (Caiazzo et al., 2011; Pang et al., 2011; Yoo et al., 2011) report that functional neurons can be directly generated from human fibroblast cells without going through the pluripotent state.

Publication types

  • Comment

MeSH terms

  • Animals
  • Electrical Synapses / metabolism*
  • Fibroblasts / metabolism*
  • Humans
  • Motor Neurons / metabolism*
  • Spinal Cord / metabolism*
  • Transcription Factors / metabolism*

Substances

  • Transcription Factors