TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

Cell Stem Cell. 2011 Sep 2;9(3):193-204. doi: 10.1016/j.stem.2011.08.007.

Abstract

One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 5-Methylcytosine / analogs & derivatives
  • 5-Methylcytosine / metabolism
  • Animals
  • Cell Differentiation*
  • Cell Transformation, Neoplastic
  • DNA Methylation
  • DNA-Binding Proteins / metabolism*
  • Epigenesis, Genetic
  • Gene Expression Regulation, Developmental
  • Hematologic Neoplasms / genetics
  • Hematologic Neoplasms / metabolism*
  • Hematologic Neoplasms / pathology
  • Humans
  • Mixed Function Oxygenases
  • Myeloid Cells / metabolism*
  • Myeloid Cells / pathology
  • Proto-Oncogene Proteins / metabolism*
  • Stem Cells / metabolism*
  • Stem Cells / pathology

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • 5-Methylcytosine
  • Mixed Function Oxygenases
  • TET1 protein, human