Inclusion body myositis

Curr Opin Rheumatol. 2011 Nov;23(6):574-8. doi: 10.1097/BOR.0b013e32834b53cc.


Purpose of review: Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized.

Recent findings: Recent findings for sIBM include further characterization of muscle involvement through magnetic resonance imaging, the role of muscle as a host for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the discovery of a new sIBM autoantibody.

Summary: sIBM understanding continues to advance, with progress regarding the mechanism of this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoantibodies / blood
  • B-Lymphocytes / immunology
  • Cell Nucleus / pathology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Magnetic Resonance Imaging
  • Myositis, Inclusion Body / diagnosis
  • Myositis, Inclusion Body / etiology*
  • Myositis, Inclusion Body / immunology
  • T-Lymphocytes / immunology


  • Autoantibodies
  • DNA-Binding Proteins