Background: Secondary erythromelalgia can occur due to various underlying medical disorders or drug toxicity.
Main observations: A 75-year old male developed acute secondary erythromelalgia following the onset of rosuvastatin use and associated myopathy. The illness was reversible after discontinuation of the pharmacological agent.
Conclusion: Secondary erythromelalgia may occur after rosuvastatin use, but this and other dermatological toxicities are rare.
Keywords: drug toxicity; erythromelalgia; rosuvastatin; statins.