The use of D-Dimer assay by enzyme immunoassay and latex agglutination techniques in the diagnosis of deep vein thrombosis

Clin Lab Haematol. 1990;12(1):37-42. doi: 10.1111/j.1365-2257.1990.tb01108.x.


The blood of 107 patients undergoing venography for suspected deep vein thrombosis (DVT) was tested for D-Dimers using enzyme immunoassay (EIA) and two latex agglutination techniques. D-Dimer levels by EIA were raised in 88% of patients with proven DVT. However, levels detected with the two agglutination tests were much less sensitive, being raised in only 43% patients with DVT. A more sensitive rapid screening test is needed to provide a useful non-invasive test for the exclusion of DVT.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Humans
  • Immunoenzyme Techniques
  • Latex Fixation Tests
  • Male
  • Middle Aged
  • Thrombophlebitis / blood
  • Thrombophlebitis / diagnosis*


  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D