[Current status of genome research on open-angle glaucoma in Finland]

Duodecim. 2011;127(14):1426-31.
[Article in Finnish]

Abstract

Loss of vision and visual impairment due to glaucoma can be prevented or delayed, if the disease is detected at an early stage. The most important risk factors for open-angle glaucoma include age, elevated intraocular pressure, exfoliation of the lens, i.e. exfoliation syndrome, and genetic factors. To date, genetic studies on glaucoma have revealed more than 20 gene loci and three candidate genes, myocilin (MYOC), optineurin (OPTN) and WD repeat domain 36 (WDR36). A mutation in both the MYOC and WDR36 genes has been found in Finnish families.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins
  • Cytoskeletal Proteins / genetics
  • Eye Proteins / genetics
  • Finland / epidemiology
  • Genome, Human*
  • Glaucoma, Open-Angle / epidemiology
  • Glaucoma, Open-Angle / genetics*
  • Glycoproteins / genetics
  • Humans
  • Membrane Transport Proteins
  • Mutation
  • Transcription Factor TFIIIA / genetics

Substances

  • Cell Cycle Proteins
  • Cytoskeletal Proteins
  • Eye Proteins
  • Glycoproteins
  • Membrane Transport Proteins
  • OPTN protein, human
  • Transcription Factor TFIIIA
  • WDR36 protein, human
  • trabecular meshwork-induced glucocorticoid response protein