World Kidney Day is observed on March 10 every year and in 2011 the 6th annual event is going to be celebrated under the joint sponsorers - International Society of Nephrology and the International Federation of Kidney Foundations. The presence of chronic kidney disease significantly increases the risk of a cardiovascular event in both diabetes and hypertension. Proteinuria is always a marker of kidney disease. The time to development of a cardiovascular event is accelerated significantly by the presence of proteinuria at all levels of glomerular filtration rate. It is suggested that renal-targeted interventions designed to reduce proteinuria and slow progression of chronic renal disease can reduce cardiovascular disease. The biomarkers of chronic kidney disease (proteinuria, eGFR) are easy and relatively inexpensive to detect and one of these, proteinuria emerges early in the generalised vascular disease.