Nandrolone and resistance training induce heart remodeling: role of fetal genes and implications for cardiac pathophysiology

Life Sci. 2011 Oct 24;89(17-18):631-7. doi: 10.1016/j.lfs.2011.08.004. Epub 2011 Aug 17.

Abstract

Aims: This study was conducted to assess the isolated and combined effects of nandrolone and resistance training on cardiac morphology, function, and mRNA expression of pathological cardiac hypertrophy markers.

Main methods: Wistar rats were randomly divided into four groups and submitted to 6 weeks of treatment with nandrolone and/or resistance training. Cardiac parameters were determined by echocardiography. Heart was analyzed for collagen infiltration. Real-time RT-PCR was used to assess the pathological cardiac hypertrophy markers.

Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased the cardiac collagen content, and reduced the cardiac index in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the ratio of maximum early to late transmitral flow velocity in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the alpha-myosin heavy chain gene expression in both non-trained and trained groups, when compared with the respective vehicle-treated groups. Training reduced the beta-myosin heavy chain gene expression in the groups treated with vehicle and nandrolone. Only the association between training and nandrolone increased the expression of the skeletal alpha-actin gene and atrial natriuretic peptide in the left ventricle.

Significance: This study indicated that nandrolone, whether associated with resistance training or not, induces cardiac hypertrophy, which is associated with enhanced collagen content, re-expression of fetal genes the in left ventricle, and impaired diastolic and systolic function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anabolic Agents / pharmacology*
  • Animals
  • Body Weight / drug effects
  • Cardiomegaly / chemically induced*
  • Cardiomegaly / genetics
  • Cardiomegaly / physiopathology*
  • Collagen / analysis
  • Diastole / drug effects
  • Echocardiography
  • Gene Expression Regulation
  • Heart / drug effects*
  • Heart / physiopathology*
  • Male
  • Myocardium / metabolism
  • Nandrolone / pharmacology*
  • Rats
  • Rats, Wistar
  • Resistance Training*
  • Systole / drug effects
  • Testosterone / blood

Substances

  • Anabolic Agents
  • Testosterone
  • Nandrolone
  • Collagen