Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats

Physiol Behav. 2012 Jan 18;105(2):209-14. doi: 10.1016/j.physbeh.2011.08.020. Epub 2011 Aug 24.


Significant sex differences have been demonstrated in clinical and preclinical studies of cocaine addiction, with some of the most consistent differences noted in regard to the role of stress and craving. The current study examined stress-induced reinstatement of cocaine seeking in male and female rats in an animal model of relapse using corticotropin-releasing factor (CRF) administration. Both male and female rats demonstrated increased cocaine seeking in response to CRF. CRF-induced reinstatement was highly variable across both male and female rats, and further analysis revealed a subpopulation that was particularly sensitive to CRF (high responders). Female high responders displayed significantly increased responding to CRF compared to males. Individual differences in stress responsivity could thus contribute to the likelihood of relapse, with females showing greater heterogeneity to stress-induced relapse.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analysis of Variance
  • Anesthetics, Local / administration & dosage*
  • Angiotensins / administration & dosage
  • Animals
  • Cocaine / administration & dosage*
  • Conditioning, Operant / drug effects*
  • Corticotropin-Releasing Hormone / pharmacology*
  • Dose-Response Relationship, Drug
  • Drinking Behavior / drug effects
  • Extinction, Psychological / drug effects
  • Female
  • Infusions, Intraventricular
  • Male
  • Rats
  • Reinforcement, Psychology*
  • Self Administration
  • Sex Characteristics*
  • Stress, Psychological / physiopathology*


  • Anesthetics, Local
  • Angiotensins
  • Corticotropin-Releasing Hormone
  • Cocaine