Contacts with children and young people and adult risk of suffering herpes zoster

Vaccine. 2011 Oct 13;29(44):7602-5. doi: 10.1016/j.vaccine.2011.08.023. Epub 2011 Sep 1.


We carried out a matched case-control study to analyze the possible association between exposure to the children and the risk of suffering herpes-zoster in adulthood. Cases of herpes zoster in immunocompetent healthy patients aged ≥ 25 years seen in the dermatology department of the Sagrado Corazón Hospital in 2007-2008 were matched with four controls. Data were analyzed using conditional logistic regression. 153 cases and 604 matched controls were included. Contacts with children were significantly associated with a reduction in the risk of suffering herpes zoster in adulthood (adjusted OR 0.56 [0.37-0.85]). Herpes-zoster vaccination in immunocompetent people aged ≥ 50 years could counteract the possible negative effects of mass varicella vaccination in childhood on the epidemiology of herpes zoster in adults.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Herpes Zoster / epidemiology*
  • Herpes Zoster / immunology
  • Herpes Zoster Vaccine / administration & dosage
  • Herpes Zoster Vaccine / immunology
  • Humans
  • Male
  • Middle Aged
  • Risk Assessment
  • Spain / epidemiology


  • Herpes Zoster Vaccine