Surgical site infections (SSIs) are a significant source of morbidity, mortality, and cost associated with small animal surgery. The most well-established strategies to reduce the impact of SSI are preventive, focusing on bolstering host immunity while decreasing wound contamination during surgery. When SSI is identified, the use of consistent definitions and culture-based therapy help to facilitate surveillance and appropriate management. Debridement and open wound management of infected wounds are important for successful treatment.