Review
doi: 10.1016/j.ecl.2011.05.009.
Epub 2011 Jun 29.
Estrogen carcinogenesis in breast cancer
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- PMID: 21889715
- DOI: 10.1016/j.ecl.2011.05.009
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Review
Estrogen carcinogenesis in breast cancer
Endocrinol Metab Clin North Am.
2011 Sep.
Abstract
Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.
Copyright © 2011 Elsevier Inc. All rights reserved.
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