Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy

J Psychopharmacol. 2012 Mar;26(3):368-73. doi: 10.1177/0269881111415736. Epub 2011 Sep 2.


A number of candidate genes for lithium prophylactic efficacy have been proposed, some of them being also associated with a predisposition to bipolar illness. The aim of the present study was to investigate a possible association between polymorphisms of 14 common genes with the quality of prophylactic lithium response in patients with bipolar mood disorder, in relation to the putative role of these genes in the pathogenesis of this disorder. Some association with lithium prophylactic efficacy was found for the polymorphisms of 5HTT, DRD1, COMT, BDNF and FYN genes, but not for 5HT2A, 5HT2C, DRD2, DRD3, DRD4, GSK-3, NTRK2, GRIN2B and MMP-9. Possible aspects of these genes with regard to the mechanism of lithium activity and pathogenesis of bipolar mood disorder are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amino Acid Substitution
  • Antimanic Agents / therapeutic use
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / genetics
  • Bipolar Disorder / metabolism
  • Bipolar Disorder / prevention & control*
  • Brain-Derived Neurotrophic Factor / genetics*
  • Brain-Derived Neurotrophic Factor / metabolism
  • Catechol O-Methyltransferase / genetics
  • Catechol O-Methyltransferase / metabolism
  • Diagnostic and Statistical Manual of Mental Disorders
  • Drug Resistance
  • Female
  • Genetic Association Studies
  • Humans
  • Lithium Carbonate / therapeutic use*
  • Male
  • Middle Aged
  • Poland
  • Polymorphism, Single Nucleotide*
  • Proto-Oncogene Proteins c-fyn / genetics*
  • Proto-Oncogene Proteins c-fyn / metabolism
  • Receptors, Dopamine D1 / genetics*
  • Receptors, Dopamine D1 / metabolism
  • Secondary Prevention
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Serotonin Plasma Membrane Transport Proteins / metabolism


  • Antimanic Agents
  • Brain-Derived Neurotrophic Factor
  • Receptors, Dopamine D1
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Lithium Carbonate
  • Catechol O-Methyltransferase
  • FYN protein, human
  • Proto-Oncogene Proteins c-fyn