A Member of the Ras Gene Superfamily Is Expressed Specifically in T, B and Myeloid Hemopoietic Cells

Oncogene. 1990 May;5(5):769-72.

Abstract

A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / physiology
  • Base Sequence
  • Blotting, Northern
  • Gene Expression / physiology
  • Hematopoietic System / cytology*
  • Hematopoietic System / metabolism
  • Hematopoietic System / physiology
  • Humans
  • Mice
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Protein-Tyrosine Kinases / physiology
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins p21(ras)
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / physiology

Substances

  • Oligonucleotide Probes
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)