The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Nat Cell Biol. 2011 Sep 2;13(9):1016-23. doi: 10.1038/ncb2329.


One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Autophagy / physiology*
  • Cell Polarity / physiology
  • Cell Proliferation*
  • Eukaryota / cytology
  • Eukaryota / metabolism
  • Humans
  • Models, Biological
  • Protein Subunits / metabolism
  • Signal Transduction / physiology*


  • Protein Subunits
  • AMP-Activated Protein Kinases