Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis

Niranjan Kumar Namelikonda; Roman Manetsch

doi:10.1039/c1cc14724b

Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis

Chem Commun (Camb). 2012 Feb 1;48(10):1526-8. doi: 10.1039/c1cc14724b. Epub 2011 Sep 5.

Authors

Niranjan Kumar Namelikonda¹, Roman Manetsch

Affiliation

¹ Department of Chemistry, University of South Florida, 4202 E Fowler Ave., Tampa, FL 33620, USA.

PMID: 21892513
DOI: 10.1039/c1cc14724b

Abstract

Herein, we describe a practical, one-pot variant of the sulfo-click reaction, in which 9-fluorenylmethyl-protected thioesters are rapidly deprotected and reacted further with sulfonylazides to give N-acyl sulfonamides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azides / chemistry*
Click Chemistry
Esters / chemical synthesis
Esters / chemistry*
Kinetics
Molecular Structure
Sulfhydryl Compounds / chemistry*
Sulfonamides / chemical synthesis*
Sulfonamides / chemistry

Substances

Azides
Esters
Sulfhydryl Compounds
Sulfonamides