MiR-483-5p controls angiogenesis in vitro and targets serum response factor

FEBS Lett. 2011 Oct 3;585(19):3095-100. doi: 10.1016/j.febslet.2011.08.039. Epub 2011 Sep 1.


Angiogenesis, a key factor in ischemic heart disease, is rapidly initiated in response to hypoxic or ischemic conditions. MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement of these RNAs in the control of angiogenesis renders them very attractive in the development of new approaches for restoring the angiogenic balance. In the present study, we explored that miR-483-5p, a microRNA embedded in the intron of insulin-like growth factor 2 (Igf2), acts as an endogenous angiogenesis-inhibiting factor. We identified that serum response factor (SRF) is one of miR-483-5p target genes. These findings indicated that the miR-483-5p-SRF pathway may offer a novel strategy for treatment with angiogenesis in ischemic heart disease patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Cell Line
  • Endothelial Cells / cytology
  • Endothelial Cells / physiology
  • Gene Expression Regulation
  • Humans
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism
  • Introns
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Neovascularization, Physiologic / physiology*
  • Serum Response Factor / genetics
  • Serum Response Factor / metabolism*
  • Signal Transduction / physiology


  • 3' Untranslated Regions
  • MIRN483 microRNA, human
  • MicroRNAs
  • Serum Response Factor
  • Insulin-Like Growth Factor II