Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation

Blood Purif. 2011;32(4):310-6. doi: 10.1159/000330325. Epub 2011 Sep 2.


Background/aim: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE.

Materials and methods: Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX.

Results: PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column.

Conclusion: PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE.

MeSH terms

  • Aged
  • Female
  • HMGB1 Protein / blood*
  • Hemoperfusion* / methods
  • Humans
  • Idiopathic Pulmonary Fibrosis / blood*
  • Idiopathic Pulmonary Fibrosis / therapy*
  • Male
  • Middle Aged
  • Oxygen / analysis
  • Polymyxin B / chemistry
  • Polymyxin B / therapeutic use*
  • Treatment Outcome


  • HMGB1 Protein
  • Polymyxin B
  • Oxygen