Helicobacter pylori resistance to rifabutin in the last 7 years

Toshihiro Nishizawa; Hidekazu Suzuki; Juntaro Matsuzaki; Hiroe Muraoka; Hitoshi Tsugawa; Kenro Hirata; Toshifumi Hibi

doi:10.1128/AAC.05437-11

Helicobacter pylori resistance to rifabutin in the last 7 years

Antimicrob Agents Chemother. 2011 Nov;55(11):5374-5. doi: 10.1128/AAC.05437-11. Epub 2011 Sep 6.

Authors

Toshihiro Nishizawa¹, Hidekazu Suzuki, Juntaro Matsuzaki, Hiroe Muraoka, Hitoshi Tsugawa, Kenro Hirata, Toshifumi Hibi

Affiliation

¹ Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Abstract

A low rate of resistance (0.24%) to rifabutin was noted in Helicobacter pylori strains isolated from 414 Japanese patients. The only rifabutin-resistant strain detected showed a point mutation in the rpoB gene and was isolated from a patient with a history of rifampin treatment for pulmonary tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Bacterial Proteins / genetics
Drug Resistance, Bacterial / genetics
Female
Helicobacter Infections / microbiology
Helicobacter pylori / drug effects*
Helicobacter pylori / pathogenicity
Humans
Male
Middle Aged
Point Mutation
Rifabutin / therapeutic use*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Rifabutin