Aspergillus oryzae laeA regulates kojic acid synthesis genes

Biosci Biotechnol Biochem. 2011;75(9):1832-4. doi: 10.1271/bbb.110235. Epub 2011 Sep 7.


Kojic acid synthesis genes regulation was investigated in Aspergillus oryzae. Our results indicate that kojic acid production was lost in the laeA disruption strain, but was recovered in the LaeA complement strain. Real-time PCR also confirmed that expression of kojic acid biosynthesis genes decreased in the laeA disruption strain, indicating that these genes are under the control of LaeA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus oryzae* / enzymology
  • Aspergillus oryzae* / genetics
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Gene Deletion
  • Gene Expression Regulation, Fungal*
  • Genetic Complementation Test
  • Methyltransferases / genetics
  • Methyltransferases / metabolism*
  • Physical Chromosome Mapping
  • Pyrones / metabolism*
  • Real-Time Polymerase Chain Reaction


  • Fungal Proteins
  • Pyrones
  • kojic acid
  • Methyltransferases