Hordeum vulgare hull in the design of fast disintegrating tablets

J Young Pharm. 2011 Jul;3(3):211-5. doi: 10.4103/0975-1483.83763.


In the present study, fast disintegrating tablets were designed with a view to enhance patient compliance. In this method, the hull of Hordeum vulgare, cross carmellose sodium, and sodium starch glycolate were used as superdisintegrants (4 and 6%), along with microcrystalline cellulose and mannitol, to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on the in vitro dispersion time, the formulations were tested for the in vitro drug release pattern. Tablets having H. vulgare hull showed the release profile comparable to those tablets having sodium starch glycolate and cross carmellose sodium.

Keywords: Cross carmellose sodium; Hordeum vulgare hull; fast disintegrating tablet; in-vitro dissolution study; sodium starch glycolate.