Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder

Int J Med Sci. 2011;8(7):523-8. doi: 10.7150/ijms.8.523. Epub 2011 Aug 30.


Objective: The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children.

Study design: MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms.

Results: Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033).

Conclusions: Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.

Keywords: Attention deficit-hyperactivity disorder; folic acide; methylenetetrahydrofolate reductase gene polymorphism.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / epidemiology
  • Attention Deficit Disorder with Hyperactivity / genetics*
  • Child
  • Female
  • Folic Acid / blood
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Impulsive Behavior / genetics
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Polymorphism, Single Nucleotide*
  • Sample Size
  • Turkey / epidemiology


  • Folic Acid
  • Methylenetetrahydrofolate Reductase (NADPH2)