Abstract
The development of a microwave-assisted, intermolecular S(N)Ar protocol for the synthesis of a 126-member benzothiaoxazepine-1,1-dioxide library is reported. Diversification of 12 benzothiaoxazepine-1,1-dioxides was achieved in rapid fashion utilizing a variety of 2° amines and amino alcohols to generate an 80-member library. A second 48-member library was subsequently generated via a two-step alkylation, intermolecular S(N)Ar diversification protocol.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Amino Alcohols / chemistry
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Benzothiadiazines / chemical synthesis*
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Benzothiadiazines / chemistry
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Combinatorial Chemistry Techniques / methods*
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Microwaves*
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Models, Chemical
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Oxazepines / chemical synthesis*
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Oxazepines / chemistry
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Oxides / chemical synthesis*
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Oxides / chemistry
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Sulfonamides / chemistry
Substances
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Amino Alcohols
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Benzothiadiazines
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Oxazepines
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Oxides
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Sulfonamides