Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases

Curr Pharm Des. 2011;17(31):3356-73. doi: 10.2174/138161211798072535.

Abstract

Several sporadic neurodegenerative diseases display phenomena that directly or indirectly relate to mitochondrial function. Data suggesting altered mitochondrial function in these diseases could arise from mitochondrial DNA (mtDNA) are reviewed. Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA, Mitochondrial / genetics*
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Humans
  • Mitochondria / genetics*
  • Mitochondria / metabolism*
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / metabolism*

Substances

  • DNA, Mitochondrial