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, 97 (3), 260-5

What Causes Attention Deficit Hyperactivity Disorder?


What Causes Attention Deficit Hyperactivity Disorder?

Anita Thapar et al. Arch Dis Child.


Attention deficit hyperactivity disorder (ADHD) affects around 1-3% of children. There is a high level of comorbidity with developmental and learning problems as well as with a variety of psychiatric disorders. ADHD is highly heritable, although there is no single causal risk factor and non-inherited factors also contribute to its aetiology. The genetic and environmental risk factors that have been implicated appear to be associated with a range of neurodevelopmental and neuropsychiatric outcomes, not just ADHD. The evidence to date suggests that both rare and multiple common genetic variants likely contribute to ADHD and modify its phenotype. ADHD or a similar phenotype also appears to be more common in extreme low birth weight and premature children and those exposed to exceptional early adversity. In this review, the authors consider recent developments in the understanding of risk factors that influence ADHD.

Conflict of interest statement

Competing interests: None.


Figure 1
Figure 1
Mother's genes can influence ADHD as well as exposure to certain environmental factors.

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    1. Meltzer H. The mental health of children and adolescents in Great Britain. London: The Stationery Office; 2000
    1. Ford T, Goodman R, Meltzer H. The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders. J Am Acad Child Adolesc Psychiatry 2003;42:1203–11 - PubMed
    1. Barkley RA, Fischer M, Smallish L, et al. Young adult follow-up of hyperactive children: antisocial activities and drug use. J Child Psychol Psychiatry 2004;45:195–211 - PubMed
    1. Barkley RA, Fischer M, Smallish L, et al. Young adult outcome of hyperactive children: adaptive functioning in major life activities. J Am Acad Child Adolesc Psychiatry 2006;45:192–202 - PubMed
    1. Thapar A, Langley K, Asherson P, et al. Gene–environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. Br J Psychiatry 2007;190:1–3 - PubMed

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