N-acetylcysteine supplementation controls total antioxidant capacity, creatine kinase, lactate, and tumor necrotic factor-alpha against oxidative stress induced by graded exercise in sedentary men

Oxid Med Cell Longev. 2011;2011:329643. doi: 10.1155/2011/329643. Epub 2011 Aug 23.

Abstract

Aim of this study was to evaluate the effects of short-term (7 days) N-acetylcysteine (NAC) at 1,200 mg daily supplementation on muscle fatigue, maximal oxygen uptake (VO(2max)), total antioxidant capacity (TAC), lactate, creatine kinase (CK), and tumor necrotic factor-alpha (TNF-α). Twenty-nine sedentary men (13 controls; 16 in the supplement group) from a randomized control were included. At before and after supplementation, fatigue index (FI) was evaluated in the quadriceps muscle, and performed a graded exercise treadmill test to induce oxidative stress, and as a measure of VO(2max). Blood samples were taken before exercise and 20 minutes after it at before and after supplementation, to determine TAC, CK, lactate, and TNF-α levels. Results showed that FI and VO(2max) increased significantly in the supplement group. After exercise decreased the levels of TAC and increased lactate, CK, and TNF-α of both groups at before supplementation. After supplementation, lactate, CK, and TNF-α levels significantly increased and TAC decreased after exercise in the control group. Whereas the TAC and lactate levels did not change significantly, but CK and TNF-α increased significantly in the supplement group. Therefore, this results showed that NAC improved the muscle fatigue, VO(2max), maintained TAC, controlled lactate production, but had no influence on CK and TNF-α.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acetylcysteine / pharmacology*
  • Adult
  • Antioxidants / metabolism*
  • Creatine Kinase / blood*
  • Exercise / physiology*
  • Humans
  • Lactic Acid / blood*
  • Male
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism
  • Oxidative Stress / drug effects*
  • Tumor Necrosis Factor-alpha / blood*
  • Young Adult

Substances

  • Antioxidants
  • Tumor Necrosis Factor-alpha
  • Lactic Acid
  • Creatine Kinase
  • Acetylcysteine