Treatment with Astragalus membranaceus produces antioxidative effects and attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in rats

Am J Chin Med. 2011;39(5):879-87. doi: 10.1142/S0192415X11009275.


Astragalus membranaceus, also known as huang qi, a traditional Chinese medicine, is often used in formulas for deficiency of vital energy characterized by limb weakness, pale face, and dizziness. Previous studies have shown that Astragalus membranaceus could attenuate intestinal ischemia-reperfusion injury induced by hemorrhagic shock in rats; however, the underlying mechanism still remains unclear. Using a hemorrhagic shock rat model to examine the effect of Astragalus membranaceus on intestinal mucosa injury induced by ischemia-reperfusion, we found that treatment (20 g crude drugs/kg, i.v.) produced antioxidative effects in the intestinal mucosa of rats after ischemia-reperfusion (p < 0.05). We also found that Astragalus membranaceus could partly attenuate intestinal mucosa ischemia-reperfusion injury (chiu's score, apoptosis index p < 0.05). These results suggest that Astragalus membranaceus reduces intestinal mucosa injury induced by ischemia-reperfusion in rats, at least in part, through its anti-oxidative effects.

MeSH terms

  • Animals
  • Antioxidants / therapeutic use*
  • Astragalus propinquus / chemistry*
  • Disease Models, Animal
  • Humans
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / injuries
  • Intestinal Mucosa / metabolism*
  • Male
  • Malondialdehyde / metabolism
  • Oxidative Stress / drug effects
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury / drug therapy*
  • Reperfusion Injury / metabolism


  • Antioxidants
  • Plant Extracts
  • Malondialdehyde