Stereoselective borylative ketone-diene coupling

Org Lett. 2011 Oct 7;13(19):5267-9. doi: 10.1021/ol202138v. Epub 2011 Sep 12.

Abstract

In the presence of catalytic Ni(cod)(2) and P(t-Bu)(3), ketones, dienes, and B(2)(pin)(2) undergo a stereoselective multicomponent coupling reaction. Upon oxidation, the reaction furnishes 1,3-diols as the major reaction product.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Boron / chemistry*
  • Ketones / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Stereoisomerism

Substances

  • Ketones
  • Boron