Abstract
It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Colonic Neoplasms / drug therapy
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Flavonoids / chemistry*
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Flavonoids / pharmacology*
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Humans
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Models, Molecular
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B / immunology
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Structure-Activity Relationship
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Tumor Necrosis Factor-alpha / immunology
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Flavonoids
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NF-kappa B
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Tumor Necrosis Factor-alpha