Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6036-41. doi: 10.1016/j.bmcl.2011.08.077. Epub 2011 Aug 22.


It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Colonic Neoplasms / drug therapy
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Humans
  • Models, Molecular
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / immunology
  • Structure-Activity Relationship
  • Tumor Necrosis Factor-alpha / immunology


  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Flavonoids
  • NF-kappa B
  • Tumor Necrosis Factor-alpha