Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

Cell Death Differ. 2011 Oct;18(10):1545-6. doi: 10.1038/cdd.2011.100.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / deficiency
  • Apoptosis Regulatory Proteins / genetics
  • BH3 Interacting Domain Death Agonist Protein / deficiency
  • BH3 Interacting Domain Death Agonist Protein / genetics
  • Cytochromes c / metabolism
  • Intracellular Membranes / metabolism
  • Membrane Proteins / deficiency
  • Membrane Proteins / genetics
  • Mice
  • Mice, Knockout
  • Mitochondria / metabolism
  • Protein Multimerization
  • Tumor Suppressor Proteins / deficiency
  • Tumor Suppressor Proteins / genetics
  • bcl-2 Homologous Antagonist-Killer Protein / chemistry
  • bcl-2 Homologous Antagonist-Killer Protein / genetics
  • bcl-2 Homologous Antagonist-Killer Protein / metabolism*
  • bcl-2-Associated X Protein / chemistry
  • bcl-2-Associated X Protein / genetics
  • bcl-2-Associated X Protein / metabolism*

Substances

  • Apoptosis Regulatory Proteins
  • BH3 Interacting Domain Death Agonist Protein
  • Membrane Proteins
  • Tumor Suppressor Proteins
  • bcl-2 Homologous Antagonist-Killer Protein
  • bcl-2-Associated X Protein
  • Cytochromes c