Hydroxyapatite coating on magnesium with MgF₂ interlayer for enhanced corrosion resistance and biocompatibility

J Mater Sci Mater Med. 2011 Nov;22(11):2437-47. doi: 10.1007/s10856-011-4431-3. Epub 2011 Sep 10.


Hydroxyapatite (HA) was coated onto pure magnesium (Mg) with an MgF(2) interlayer in order to reduce the surface corrosion rate and enhance the biocompatibility. Both MgF(2) and HA were successfully coated in sequence with good adhesion properties using the fluoride conversion coating and aerosol deposition techniques, respectively. In a simulated body fluid (SBF), the double layer coating remarkably enhanced the corrosion resistance of the coated Mg specimen. The in vitro cellular responses of the MC3T3-E1 pre-osteoblasts were examined using a cell proliferation assay and an alkaline phosphatase (ALP) assay, and these results demonstrated that the double coating layer also enhanced cell proliferation and differentiation levels. In the in vivo study, the HA/MgF(2) coated Mg corroded less than the bare Mg and had a higher bone-to-implant contact (BIC) ratio in the cortical bone area of the rabbit femora 4 weeks after implantation. These in vitro and in vivo results suggested that the HA coated Mg with the MgF(2) interlayer could be used as a potential candidate for biodegradable implant materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Absorbable Implants
  • Animals
  • Biocompatible Materials / chemistry*
  • Bone Substitutes
  • Corrosion
  • Durapatite / chemistry*
  • Fluorides / chemistry*
  • Magnesium Compounds / chemistry*
  • Materials Testing
  • Mice
  • Rabbits
  • Surface Properties


  • Biocompatible Materials
  • Bone Substitutes
  • Magnesium Compounds
  • magnesium fluoride
  • Durapatite
  • Fluorides