Long-term prognostic value of coronary flow velocity reserve in renal transplant recipients

Transplant Proc. 2011 Sep;43(7):2612-6. doi: 10.1016/j.transproceed.2011.05.046.


Background: In this prospective study, we sought to investigate the long-term prognostic value of coronary flow reserve (CFR) and carotid intima media thickness (IMT) estimates in renal transplant recipients without known coronary artery disease.

Methods: The 20 renal transplant recipients included in this study underwent CFR recordings performed by trans-thoracic Doppler echocardiography (TTDE) and carotid IMT measured by carotid Doppler ultrasonography.

Results: During a 3-year follow-up only one patient experienced a cardiac event. The baseline CFR and carotid IMT values of the patients were 1.77 ± 0.47 and 0.67 ± 0.15 mm, respectively. After 3 years of follow-up, there were no significant differences compared with baseline measurements with regard to CFR and IMT values. CFR values at the third year of follow-up showed significant correlation with age as well as IMT at baseline and at the third year. Upon multivariate analysis, baseline carotid IMT (β = -0.562; P = .05) was a significant independent predictor of CFR at the third year.

Conclusion: Carotid IMT showed a greater predictive value for impaired CFR in renal transplant recipients. CFR was not an independent predictor for cardiovascular events among renal transplant recipients within the first 3 years of follow-up measurements.

MeSH terms

  • Adult
  • Carotid Arteries / diagnostic imaging
  • Coronary Vessels / diagnostic imaging
  • Coronary Vessels / physiopathology*
  • Echocardiography, Doppler
  • Female
  • Humans
  • Kidney Transplantation*
  • Male
  • Prognosis
  • Regional Blood Flow