Effects of S-adenosylmethionine Augmentation of Serotonin-Reuptake Inhibitor Antidepressants on Cognitive Symptoms of Major Depressive Disorder

J Affect Disord. 2012 Feb;136(3):1174-8. doi: 10.1016/j.jad.2011.04.059. Epub 2011 Sep 10.

Abstract

Background: Major depressive disorder (MDD) is often accompanied by significant cognitive impairment, and there are limited interventions specific to this particular symptom. S-adenosyl methionine (SAMe), a naturally occurring molecule which serves as a major methyl-donor in human cellular metabolism, is required for the synthesis and maintenance of several neurotransmitters that have been implicated in the pathophysiology and treatment of cognitive dysfunction in MDD.

Methods: This study is a secondary analysis of a clinical trial involving the use of adjunctive SAMe for MDD. Forty-six serotonin-reuptake inhibitor (SRI) non-responders with MDD enrolled in a 6-week, double-blind, randomized trial of adjunctive oral SAMe were administered the self-rated cognitive and physical symptoms questionnaire (CPFQ), a validated measure of cognitive as well as physical symptoms of MDD, before and after treatment.

Results: There was a greater improvement in the ability to recall information (p=0.04) and a trend toward statistical significance for greater improvement in word-finding (p=0.09) for patients who received adjunctive SAMe than placebo. None of the remaining five items reached statistical significance.

Conclusion: These preliminary data suggest that SAMe can improve memory-related cognitive symptoms in depressed patients, and warrant replication.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use*
  • Cognition Disorders / complications
  • Cognition Disorders / drug therapy*
  • Depressive Disorder, Major / complications
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / psychology
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • S-Adenosylmethionine / therapeutic use*
  • Serotonin Uptake Inhibitors / therapeutic use*

Substances

  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  • S-Adenosylmethionine