Rapidly progressive Alzheimer disease

Arch Neurol. 2011 Sep;68(9):1124-30. doi: 10.1001/archneurol.2011.189.


Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs. Progressive forms of Alzheimer disease have been reported with rapid cognitive decline and disease duration of only a few years. This short review aims to provide an overview of the current knowledge of rapidly progressive Alzheimer disease. Furthermore, we suggest that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Animals
  • Clinical Trials as Topic / methods
  • Disease Progression*
  • Genetic Markers / genetics
  • Humans
  • Risk Factors
  • Time Factors


  • Genetic Markers