The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product

Mol Microbiol. 1990 Apr;4(4):585-96. doi: 10.1111/j.1365-2958.1990.tb00627.x.


A 2.1 kb DNA segment carrying the purine-cytosine permease gene (FCY2) of Saccharomyces cerevisiae was sequenced, the primary structure of the protein (533 amino acids) deduced and a folding pattern in the membrane is proposed for the permease protein. Expression of the FCY2 gene product requires a functional secretory pathway and is reduced in mnn9, a mutant strain deficient in outer chain glycosylation. The FCY2 gene was mapped on the right arm of chromosome V close to the HIS1 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • DNA, Fungal / biosynthesis*
  • Gene Amplification
  • Genes, Fungal*
  • Glycosylation
  • Membrane Transport Proteins*
  • Molecular Sequence Data
  • Molecular Weight
  • Mutation
  • Nucleobase Transport Proteins
  • Protein Conformation
  • Restriction Mapping
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*


  • Carrier Proteins
  • DNA, Fungal
  • FCY2 protein, S cerevisiae
  • Membrane Transport Proteins
  • Nucleobase Transport Proteins
  • Saccharomyces cerevisiae Proteins

Associated data

  • GENBANK/X51751