Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet

Ann Hepatol. Oct-Dec 2011;10(4):486-92.


Objective: To evaluate the efficacy of low carbohydrate diet (LCD) as compared with low fat diet (LFD) to decrease aminotransferase levels in obese women with nonalcoholic fatty liver disease.

Material and methods: A total of 59 women were randomly enrolled in a non-controlled clinical intervention study to receive either LCD or LFD during six months. Apparently healthy non-pregnant obese women aged 20 to 65 years were eligible to participate. Previous diagnosis of hepatic disease, serum creatinine level ≥ 1.5 mg/dL, severe life-limiting medical illness, pregnancy, active participation in other dietary program, use of weight loss drugs, or alcohol consumption ≥ 30 g per day were exclusion criteria.

Results: A total of 31 obese women who received LCD were compared with 28 women allocated in the LFD group. There were 3 (LCD group) and 2 (LFD group) women with lost of follow-up. No differences in the proportion of type 2 diabetes, hypertension and hyperlipidemia were noted between women in the LCD and LFD groups. At end of follow-up, there were not significant statistical differences in the anthropometric and biochemical characteristics between women in both groups. The weight loss was 5.7 and 5.5% for women in the LCD LFD groups. Although the decrease of AST (31.7 and 22.4%) and ALT (41 and 33.3%) levels was more elevated in the women of LCD group, as compared with the LFD group, there were not significant statistical differences.

Conclusions: Our results show that weight loss, irrespective of the type of diet, reduces aminotransferase levels in obese women with NAFLD.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alanine Transaminase / blood*
  • Aspartate Aminotransferases / blood*
  • Biomarkers / blood
  • Chi-Square Distribution
  • Diet, Carbohydrate-Restricted*
  • Diet, Fat-Restricted*
  • Down-Regulation
  • Fatty Liver / blood
  • Fatty Liver / etiology*
  • Female
  • Humans
  • Mexico
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease
  • Obesity / blood
  • Obesity / complications
  • Obesity / diet therapy*
  • Time Factors
  • Treatment Outcome
  • Weight Loss*


  • Biomarkers
  • Aspartate Aminotransferases
  • Alanine Transaminase