Aim: Determination of the effect of complex vaccination with Pneumo-23, Hiberix, Grippol plus on sputum bacterial content 6 months after the vaccination of patients with chronic obstructive pulmonary disease (COPD) compared with unvaccinated patients.
Materials and methods: Bacteriological analysis of sputum obtained for 6 months from 80 patients with COPD was carried out. The first group of 31 patients with COPD was immunized simultaneously with Pneumo-23, Hiberix, Grippol plus (mean age--59.25 +/- 1.12). The second group consisted of 49 unvaccinated patients with COPD (mean age--57.16 +/- 0.98). Classical microbiological method was used in the study.
Results: 6 months after the complex vaccination a significant decrease to 35.48 +/- 8.59% of vaccinated patients, that expectorate sputum with Streptococcus pneumoniae, compared with 80.65 +/- 7.1% in unvaccinated patients with COPD was observed.
Conclusion: A combined vaccination against pneumococcal, haemophilus type b infection and influenza carried out with a prophylactic and therapeutic goal is recommended for patients with COPD as a part of the treatment and prophylaxis complex measures.